Established in 1991, Catharine Clark Gallery exhibits contemporary art in all disciplines. In response to each exhibition, the gallery curates changing presentations of video and time-based genres within a dedicated media room. Catharine Clark Gallery serves as the primary dealer for an acclaimed roster of international artists, including Stephanie Syjuco, Marie Watt, Nina Katchadourian, Jen Bervin, Lenka Clayton, Ana Teresa Fernandez, Sandow Birk, and Masami Teraoka. The gallery also co-publishes and distributes original multiples with Mullowney Printing, including projects by Alison Saar, Marie Watt, Masami Teraoka, and Sandow Birk.

The gallery's program has garnered critical attention from the New York Times,  Artforum, Art in America, i-D/Vice, and Vogue, among other publications. Works by gallery artists are held in the permanent collections of dozens of major international institutions including the Tate, Whitney Museum of American Art, Metropolitan Museum of Art, Museum of Modern Art, San Francisco Museum of Modern Art, Fine Arts Museums of San Francisco, Los Angeles County Museum of Art, the Hammer, and the Blanton Museum of Art, among many others.

In 2016, Catharine Clark founded BOXBLUR, an initiative to bring visual and performing art into dialogue within the gallery. Artist and performer collaborators include Rufus Wainwright, Catherine Galasso,  Benjamin Freemantle and Angelo Greco (San Francisco Ballet), Margaret Jenkins Dance Company, Monique Jenkinson/Fauxnique, Indira Allegra, Kambui Olujimi, Jen Bervin, and Shimon Attie, among many others.

Located within San Francisco's emerging DoReMi arts district (comprised of adjoining neighborhoods Dogpatch, Potrero Hill, and the Mission), Catharine Clark Gallery is situated in proximity to leading arts venues such as California College of the Arts (CCA), the CCA Wattis Institute for Contemporary Arts, the Museum of Craft and Design and Minnesota Street Project, as well as several contemporary fine art galleries.