Established in 1991, Catharine Clark Gallery exhibits contemporary art in all disciplines. In response to each exhibition, we also curate changing presentations of video and time-based genres within a dedicated media room. New exhibits open every six weeks. Catharine Clark Gallery serves as the primary dealer for an acclaimed roster of international artists: Sandow Birk, Lenka Clayton, Chris Doyle, Al Farrow, Nina Katchadourian, Deborah Oropallo, Stephanie Syjuco, Josephine Taylor, Masami Teraoka, and Wanxin Zhang.

The gallery's program has garnered critical attention from publications: the New York Times, Yishu, Artforum, Tema Celeste, Art in America, Art News, Art Practical, Modern Painters, i-D/Vice, and Vogue. Gallery artists have exhibited at international venues and biennials: the Tate Modern, the Museum of Modern Art, the Whitney Museum of American Art, the Metropolitan Museum of Art, the San Francisco Museum of Modern Art, the Asian Art Museum, the Serpentine Gallery, the Frans Hals Museum, the Smithsonian American Art Museum, the San Francisco Museum of Modern Art, the Mori Art Museum, the StadtReutlingen Museum, Manifesta 11, and the 56th Venice Biennale.

In 2016, Catharine Clark founded BOX BLUR, an initiative to bring visual and performing art into dialogue within the non-proscenium-based space of the gallery. In 2016, Margaret Jenkins Dance Company was commissioned to respond to Kambui Olujimi's sculptural stages. In 2017, the EOS Ensemble was commissioned to perform Jeremy Turner's score for Chris Doyle's video; in 2018, Josephine Taylor and Kaveh Rastegar engaged in a multi-media collaboration with drawing, video, and music; and for 2019's commission "How to Fall in Love in a Brothel," artists Sunhui Chang, Ellen Sebastian Chang, and Maya Gurantz built a traditional Korean screened room that served as the setting for live performance. 2020's commission features a concert by Rufus Wainwright in response to Timothy Cummings's work.

Located within San Francisco's emerging DoReMi arts district (comprised of adjoining neighborhoods Dogpatch, Potrero Hill, and the Mission), Catharine Clark Gallery is situated in proximity to leading arts venues such as California College of the Arts (CCA), the CCA Wattis Institute for Contemporary Arts, the Museum of Craft and Design and Minnesota Street Project, as well as several contemporary fine art galleries.